DPPA3 is a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this protein may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. Recombinant human DPPA3 protein, fused to His-tag at N-terminus, was expressed in E.coli .