DNAJC15 contains 1 J domain. This protein is expressed ubiquitously and located on the membrane. DNAJC15 is absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin. Recombinant human DNAJC15 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.