CYTIP, also known as cytohesin-interacting protein, contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. It modulates the activation of ARF genes by CYTH1. Recombinant CYTIP, fused to His-tag at N-terminus, was expressed in E.coli.