CRMP1 also known as Dihydropyrimidinase-related protein 1 isoform2. It is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. It plays a role in axon guidance, invasive growth and cell migration and may participate in cytokinesis. Recombinant human CRMP1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.