CLE5CA, also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL1), is a C-type lectin. It appears to be a member of a significant myeloid lineage activating pathway. This protein functions as a positive regulator of osteoclastogenesis and regulates inflammatory responses. Recombinant human CLEC5A protein, fused to His-tag at N-terminus, was expressed in E.coli.