CD300C, also known as CMRF35-like molecule 6, is a type I transmembrane glycoprotein that belongs to the immune regulatory signaling (IRS) family of molecules within the immunoglobulin (Ig) superfamily. It is present on the surface of natural killer cells, granulocytes, most myeloid cells, dendritic cells, and a subpopulation of T and B lymphocytes. This protein regulates a diverse array of cell processes via their triggering and inhibitory receptor functions. Recombinant human CD300c protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.