CCDC104 (coiled-coil domain-containing protein 104) is a 342 amino acid protein that exists as two alternatively spliced isoforms. CCDC104 undergoes post-translational phosphorylation following DNA damage, most likely by either ATR or ATM. Recombinant human CCDC104 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.