Anti-Human Phospho-p16 (Ser326) Polyclonal Antibody

Phospho-p16 (Ser326)多克隆抗体

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. 
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基本信息

数据文档 查看数据文档
货号 PA01843
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human p16 around the phosphorylation site of Ser326
特异性 Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
亚型 IgG
反应性 Human
克隆
Uniprot P42771
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
配方
应用范围 WB,IHC-p,ELISA
别名 CCM2,CDK4 inhibitor p16 INK4,CDK4I,CDKN2,CDKN2A,Cell cycle negative regulator beta,CMM2,Cyclin dependent kinase 4 inhibitor A,Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4),Cyclin Dependent Kinase Inhibitor 2A,Cyclin dependent kinase inhibitor 2A isoform 4,Cyclin dependent kinase inhibitor 2A isoforms 1/2/3,Cyclin dependent kinase inhibitor p16,INK4,INK4A,MLM,MTS1,Multiple tumor suppressor 1,p14,p16,P16INK4,p16INK4a,p19,p19Arf,TP16
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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