Anti-Human/Mouse/Rat Phospho-LEF1 (Ser42) Polyclonal Antibody

Phospho-LEF1 (Ser42)多克隆抗体

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
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基本信息

数据文档 查看数据文档
货号 PA01686
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human LEF-1 around the phosphorylation site of S42.
特异性 Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q9UJU2
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, ELISA 1:5000
配方
应用范围 WB,IF,ELISA
别名 DKFZp586H0919,FLJ46390,LEF 1,LEF-1,Lef1,LEF1,Lymphoid enhancer binding factor 1,Lymphoid enhancer-binding factor 1,T cell specific transcription factor 1 alpha,T cell-specific transcription factor 1-alpha,TCF 1 alpha,TCF1 alpha,TCF1-alpha,TCF10,TCF1alpha,TCF7L3,Transcription factor T cell specific 1 alpha
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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