The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.EPB41 (Erythrocyte Membrane Protein Band 4.1) is a Protein Coding gene. Diseases associated with EPB41 include Elliptocytosis-1 and Hereditary Elliptocytosis. Among its related pathways are Protein-protein interactions at synapses and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is EPB41L2.