DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links.DCLRE1B (DNA Cross-Link Repair 1B) is a Protein Coding gene. Diseases associated with DCLRE1B include Fanconi Anemia, Complementation Group A and Dyskeratosis Congenita. Among its related pathways are Fanconi anemia pathway and DNA Double-Strand Break Repair. GO annotations related to this gene include 5-3 exonuclease activity. An important paralog of this gene is DCLRE1C.