ANGPTL2 also known as Angiopoietin-related protein2 is members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. ANGPTL1, ANGPTL2, and ANGPTL4 participate in the formation of blood vessels. Recombinant human ANGPTL2, fused to His-tag at N-terminus, was expressed in E.coli.