ACVR2A, also known as activin receptor type-2A, is involved in a wide range of biological processes including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, the regulation of reproductive physiology, inflammation, and carcinogenesis. They function through heteromeric complexes of type I and type II serine/threonine kinase receptors. Recombinant human ACVR2A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.