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Anti-Human ZEB1 Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
ZEB1(zinc-finger-enhancer binding protein 1),which is a members of the Zincfinger-Homeobox (ZFH)-family of repressors,acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. Depending on the quantity of cDNA and on the cell type,ZEB1 can enhance or repress the promoter activity of the ATP1A1 gene . Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. The calculated molecular weight of ZEB1 is 124 kDa,but the post phosphorylation of protein is about 190-210 kDa.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA02184
Size 100μl
Host Type Mouse
Immunogen Fusion protein of ZEB1
Specificity Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
Isotype IgG1
Reacitivity Human
Clone 156
Uniprot P37275
Concentration None
Dilution WB 1:500-1:5000
Formulation
Application WB,ELISA
Other Names AREB 6,BZP,Delta crystallin enhancer binding factor 1,DELTA EF1,FECD6,MGC133261,Negative regulator of IL 2,Negative regulator of IL2,NIL 2 A,NIL 2 A zinc finger protein,NIL 2A,NIL-2-A zinc finger protein,NIL2A,Posterior polymorphous corneal dystrophy 3,PPCD3,Represses interleukin 2 expression,TCF 8,TCF-8,TCF8,Transcription factor 8 (represses interleukin 2 expression),Transcription factor 8,ZEB 1,ZEB,ZEB1,ZEB1,ZFHEP,ZFHX 1A,ZFHX1A,Zinc finger E box binding homeobox 1,Zinc finger E-box-binding homeobox 1,Zinc finger homeodomain enhancer binding protein
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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