Anti-Human/Rat PEX5 Monoclonal Antibody

The peroxisomal targeting signal type1 (PTS1) receptor,PEX5,is one member of peroxins (PEXs) which are proteins required for peroxisome assembly. PEX5 and PEX7 function as receptors that recognize PTS1- and PTS2- containing proteins,respectively,and PEX5 binds PTS1 through its C-terminal 40-kDa tetratricopeptide repeat domain. It is a predominantly cytoplasmic,partly peroxisomal protein that appears to shuttle between these compartments as it mediates the import of PTS1-containing proteins. PEX5 has been reported to interact with PEX10,PEX12,PEX13,and PEX14. Defects in PEX5 are a cause of Zellweger syndrome (ZWS),which is a lethal peroxisome biogenesis disorder.