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Anti-Human/Rat 14-3-3 theta Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
14-3-3 proteins interact with a wide spectrum of proteins and possess diverse functions. Mammals express seven distinct 14-3-3 isoforms (gamma,epsilon,beta,zeta,sigma,theta,tau) that form multiple homo- and hetero- dimmers. 14-3-3 proteins display the highest expression levels in the brain,and have been implicated in several neurodegenerative diseases,including Alzheimer's disease and amyotrophic lateral sclerosis. This antibody recognizes 14-3-3 tau (YWHAQ),eta (YWHAH),and zeta (YWHAZ),but not epsilon (YWHAE).
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Properties

Data Sheet Click for Datasheet
Catalog Number MA02186
Size 100μl
Host Type Mouse
Immunogen Fusion protein of 14-3-3
Specificity Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
Isotype IgG1
Reacitivity Human,Rat
Clone 954
Uniprot P27348
Concentration None
Dilution WB 1:500-1:5000, IHC 1:50-1:500, IF 1:20-1:200
Formulation
Application WB,IHC,IF,ELISA
Other Names 14 3 3 protein T cell,14 3 3 protein tau,14 3 3 protein theta,14 3 3 tau,14 3 3 theta,14-3-3 protein T-cell,14-3-3 protein tau,14-3-3 protein theta,1433T,1C5,HS1,KCIP1,Protein HS1,Protein kinase C inhibitor protein 1,Protein tau,tyr3/trp5 monooxygenase activation protein,theta,Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein,theta polypeptide,Ywhaq
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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