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Anti-Human RAB27A Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
Rab27a is a member of a large family of Ras-related small GTPases. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Recent studies suggest that Rab27a is associated with melanosomes in pigmented cells and regulates melanosome transport via its interaction with actin-based cellular motors such as myosin Va and myosin VIIa. RAB27A is also required for regulated secretion in cytotoxic T lymphocytes. Rab27a is implicated in several diseases,including Griscelli syndrome,choroideremia,and the Hermansky-Pudlak syndrome mouse model,gunmetal.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA02104
Size 100μl
Host Type Mouse
Immunogen Fusion protein of RAB27A
Specificity Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
Isotype IgG1
Reacitivity Human
Clone 200
Uniprot P51159
Concentration None
Dilution WB 1:500-1:5000, IHC 1:20-1:200, IF 1:50-1:500
Formulation
Application WB,IHC,IF,ELISA
Other Names GS2,GTP-binding protein Ram,HsT18676,MGC117246,Mutant Ras related protein Rab-27A,Rab-27,RAB-27A,RAB27,RAB27A,RAB27A member RAS oncogene family,RAM,Ras-related protein Rab-27A,Ras-related protein Rab27A,RB27A
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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