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Anti-Human/Mouse STMN1 Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
Stathmin 1 (STMN1) normally regulates microtubule dynamics either by sequestering free tubulin heterodimers or by promoting microtubule catastrophe. STMN1 is highly expressed in fetal and adult brain,spinal cord,and cerebellum. Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. Phosphorylation of stathmin is involved in response to NGF,neuron polarization and microtubule polymerization inhibition activity. Increased expression of STMN1 has been observed in a variety of human malignancies,such as colorectal primary tumors and metastatic tissues,but its association with melanoma is so far not well known.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA02141
Size 100μl
Host Type Mouse
Immunogen Fusion protein of Stathmin
Specificity Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
Isotype IgG1
Reacitivity Human,Mouse
Clone 34
Uniprot P16949
Concentration None
Dilution WB 1:500-1:5000, IHC 1:20-1:200, IF 1:20-1:200
Formulation
Application WB,IHC,IF,ELISA
Other Names C1orf215,Lag,LAP 18,LAP18,Leukemia associated phosphoprotein p18,Leukemia-associated phosphoprotein p18,Metablastin,Oncoprotein 18,OP 18,Op18,p18,p19,Phosphoprotein 19,Phosphoprotein p19,pp17,pp19,PR22,Pr22 protein,Prosolin,Protein Pr22,SMN,Stathmin,Stathmin1,STMN 1,Stmn1,STMN1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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