Anti-Human /Mouse /Rat SLC18A2 Polyclonal Antibody

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).SLC18A2 (Solute Carrier Family 18 Member A2) is a Protein Coding gene. Diseases associated with SLC18A2 include Brain Dopamine-Serotonin Vesicular Transport Disease and Parkinson Disease 1. Among its related pathways are Serotonergic synapse and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include enzyme binding and transmembrane transporter activity. An important paralog of this gene is SLC18A1.