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Anti-Human/Mouse/Rat PI 3 kinase p85 alpha Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
Phosphatidylinositol 3-kinase (PI3K) plays an important role in the metabolic actions of insulin and is required for adipogenesis. The PI3K pathway has also been identified as an important player in cancer development and progression. The Class IA PI3K heterodimer,which is composed of a P110 catalytic subunit and a P85 regulatory subunit,is activated upon association of the P85 subunit with upstream adaptor proteins or receptor tyrosine kinases. Mutations in PIK3R1 are implicated in cases of breast cancer and associated to SHORT syndrome.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA02087
Size 100μl
Host Type Mouse
Immunogen Fusion protein of PI3K p85(alpha)
Specificity Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Isotype IgG2a
Reacitivity Human,Mouse,Rat
Clone 645
Uniprot P27986
Concentration None
Dilution WB 1:1000-1:10000, IHC 1:20-1:200, IF 1:50-1:500
Formulation
Application WB,IHC,IF,ELISA
Other Names GRB1,p85 alpha,p85,P85A,Phosphatidylinositol 3 kinase associated p 85 alpha,Phosphatidylinositol 3 kinase regulatory 1,Phosphatidylinositol 3 kinase,regulatory subunit,polypeptide 1 (p85 alpha),Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphoinositide 3 kinase,regulatory subunit 1 (alpha),PI3 kinase p85 subunit alpha,PI3-kinase regulatory subunit alpha,PI3-kinase subunit p85-alpha,PI3K,PI3K regulatory subunit alpha,Pik3r1,PtdIns 3 kinase p85 alpha,PtdIns-3-kinase regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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