Anti-Human/Mouse/Rat Phospho-NTRK2 (Tyr516) Polyclonal Antibody

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01643
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human Trk B around the phosphorylation site of Tyr516
Specificity Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q16620
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Formulation
Application WB,IHC-p,ELISA
Other Names AI848316,BDNF tropomyosine receptor kinase B,BDNF/NT 3 growth factors receptor,BDNF/NT-3 growth factors receptor,Brain derived neurotrophic factor receptor,C030027L06Rik,EC 2.7.10.1,GP145 TrkB,GP145-TrkB,GP145-TrkB/GP95-TrkB,GP95 TrkB,Neurotrophic receptor tyrosine kinase 2,Neurotrophic tyrosine kinase receptor type 2,Neurotrophin receptor tyrosine kinase type 2,NTRK 2,Ntrk2,NTRK2,Obesity,hyperphagia,and developmental delay,included,RATTRKB1,Tkrb,Trk B,Trk-B,TRKB,TrkB tyrosine kinase,TRKB1,Tropomyosin related kinase B,tyrosine kinase receptor B,Tyrosine receptor kinase B
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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