Anti-Human/Mouse/Rat Phospho-LIMK1 (Thr508) Polyclonal Antibody

Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01586
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human LIMK-1 around the phosphorylation site of Thr508
Specificity Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot P53667
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
Formulation
Application WB,IHC-p,IF,ELISA
Other Names EC 2.7.1.37,LIM domain containing protein kinase,LIM domain kinase 1,LIM kinase,LIM motif containing protein kinase,LIMK 1,LIMK,LIMK-1,limk1,LIMK1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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