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Anti-Human/Mouse/Rat MGEA5 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT, which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications. Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. Shows highest expression in the brain, placenta and pancreas.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA12270
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human MGEA5
Specificity Ubiquitous. Shows highest expression in the brain, placenta and pancreas.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot O60502
Concentration 0.2 mg/mL
Dilution WB 1:200-1:1000, IHC 1:15-1:50
Formulation
Application WB,IHC,ELISA
Other Names Beta-hexosaminidase,Beta-N-acetylglucosaminidase,Beta-N-acetylhexosaminidase,Bifunctional protein NCOAT,HEXC,Hyaluronidase in meningioma,KIAA0679,MEA5,Meningioma expressed antigen 5,Meningioma-expressed antigen 5,MGEA 5,Mgea5,N-acetyl-beta-D-glucosaminidase,N-acetyl-beta-glucosaminidase,NCOAT,Nuclear cytoplasmic O GlcNAcase and acetyltransferase,Nuclear cytoplasmic O-GlcNAcase and acetyltransferase,OGA,OGA,Protein O-GlcNAcase
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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