Anti-Human/Mouse Phospho-TERF1 (Ser219) Polyclonal Antibody

Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01693
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human TRF1 around the phosphorylation site of S219.
Specificity Highly expressed and ubiquitous. Isoform Pin2 predominates.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot P54274
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:5000
Formulation
Application WB,ELISA
Other Names hTRF1 AS,NIMA interacting protein 2,NIMA-interacting protein 2,PIN 2,PIN2,t TRF1,Telomeric protein Pin2,Telomeric protein Pin2/TRF1,Telomeric repeat binding factor (NIMA interacting) 1,Telomeric repeat binding factor 1,Telomeric repeat binding protein 1,Telomeric repeat-binding factor 1,TERF 1,Terf1,TERF1,TRBF 1,TRBF1,TRF 1,TRF,TTAGGG repeat binding factor 1,TTAGGG repeat-binding factor 1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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