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Anti-Human FHIT Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
The candidate tumor suppressor gene,FHIT(Fragile histidine triad protein),encompasses the common human chromosomal fragile site at 3p14.2,the hereditary renal cancer translocation breakpoint,and cancer cell homozygous deletions. Fhit hydrolyzes dinucleotide 5',5'''-P1,P3-triphosphate in vitro and mutation of a central histidine abolishes hydrolase activity. FHIT has a major role in regulating beta-catenin-mediated gene transcription.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01968
Size 100μl
Host Type Mouse
Immunogen Fusion protein of FHIT
Specificity Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.
Isotype IgG1
Reacitivity Human
Clone 308
Uniprot P49789
Concentration None
Dilution WB 1:200-1:2000, IHC 1:20-1:200, IF 1:10-1:100
Formulation
Application WB,IHC,IF,ELISA
Other Names AP3A hydrolase,AP3A hydrolase fragile site 3p14.2,AP3Aase,Bis 5' adenosyl triphosphatase,Bis(5' adenosyl) triphosphatase,Diadenosine 5' 5''' P1 P3 triphosphate hydrolase,Dinucleosidetriphosphatase,FRA 3B,FRA3B,Fragile histidine triad,Fragile histidine triad gene,Fragile histidine triad protein,Tumor suppressor protein
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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