Recombinant Mouse TNFR2 Protein (His Tag)

Categories: [Proteins / Peptides]
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP08125
Size 20ug,50ug,100ug…
Host HEK293 Cells
Accession NP_035740.2
Molecular Weight 26.8 kDa
AP_Mol_Weight 45 kDa
Tag C-His
Sequences Met 1-Gly 258
Purity > 95% by HPLC
Concentration
Formulation PBS
Other Names CD120b Protein, Mouse;p75 Protein, Mouse;TNF-alphaR2 Protein, Mouse;TNF-R-II Protein, Mouse;TNF-R2 Protein, Mouse;TNF-R75 Protein, Mouse;TNFalpha-R2 Protein, Mouse;TNFBR Protein, Mouse;Tnfr-1 Protein, Mouse;Tnfr2 Protein, Mouse;TNFR80 Protein, Mouse;TNFRII Protein, Mouse
Bioactivity Measured by its ability to inhibit TNFα-mediated cytotoxicity in L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D.The ED50 for this effect is typically 1-3 µg/mL in the presence of 0.1 ng/mL of recombinant mouse TNFα.
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.

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