Recombinant Human SIRP gamma Protein (His Tag)

Categories: [Proteins / Peptides]
Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP07313
Size 20ug,50ug,100ug…
Host HEK293 Cells
Accession NP_061026.2
Molecular Weight 34.7 kDa
AP_Mol_Weight
Tag C-His
Sequences Met 1-Ser 364
Purity > 95% by HPLC
Concentration
Formulation PBS
Other Names bA77C3.1;CD172g;SIRP-B2;SIRPB2;SIRPgamma
Bioactivity Measured by its binding ability in a functional ELISA.Immobilized human SIRPG-His at 10 μg/ml (100 μl/well) can bind human CD47-Fc , The EC50 of human CD47-Fc is 0.58-1.34 μg/ml.
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.

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