Recombinant Human IL18R1 / CD218a Protein (His tag)

Categories: [Proteins / Peptides]
Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP07910
Size 20ug,50ug,100ug…
Host HEK293 Cells
Accession NP_003846.1
Molecular Weight 37.2 kDa
AP_Mol_Weight 60-70 kDa
Tag C-His
Sequences Met 1-Arg 329
Purity > 95% by HPLC
Concentration
Formulation PBS
Other Names CD218a;CDw218a;IL-1Rrp;IL18RA;IL1RRP
Bioactivity
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.

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