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Recombinant Human IL-6R Protein (His Tag)

Categories: [Proteins / Peptides]
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP08540
Size 20ug,50ug,100ug…
Host HEK293 Cells
Accession NP_000556.1
Molecular Weight 40 kDa
AP_Mol_Weight
Tag C-His
Sequences Met 1-Pro 365
Purity > 95% by HPLC
Concentration
Formulation PBS
Other Names CD126;gp80;IL-6R;IL-6R-1;IL-6RA;IL6Q;IL6RA;IL6RQ
Bioactivity Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL-6 at 8 μg/mL (100μl/well) can bind recombinant human IL6R with a linear range of 1.25-20.0 ng/ml.2. Measured by its ability to enhance the IL6 activity on M1 mouse mye
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.
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