TBC1D22B also known as TBC1 domain family member 22B. TBC1D22B may act as a GTPase-activating protein for Rab family protein. The Tre-2/Bub2/Cdc16 (TBC) domain is a conserved protein motif that consists of approximately 200 amino acids and is thought to function as a specific Rab-GAP domain. The TBC domain is more than 40 distinct TBC domain-containing proteins have been identified in humans. Recombinant human TBC1D22B was expressed in E.coli and purified by using conventional chromatography techniques