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Anti-Human/Mouse/Rat/Monkey PIAS2 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA05581
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human PIASx
Specificity Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
Isotype IgG
Reacitivity Human,Mouse,Rat,Monkey
Clone
Uniprot O75928
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:20000
Formulation
Application WB,ELISA
Other Names Androgen receptor interacting protein 3,Androgen receptor-interacting protein 3,ARIP3,DAB2 interacting protein,DAB2-interacting protein,DIP,E3 SUMO protein ligase PIAS2,E3 SUMO-protein ligase PIAS2,MIZ,Miz1,Msx interacting zinc finger protein,Msx-interacting zinc finger protein,PIAS NY protein,PIAS-NY protein,PIAS2,PIAS2,PIASX,PIASX-ALPHA,PIASX-BETA,Protein inhibitor of activated STAT x,Protein inhibitor of activated STAT,2,Protein inhibitor of activated STAT2,SIZ2,Zinc finger,MIZ-type containing 4,ZMIZ4
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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