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PTTG1, 1-202 aa, Human, His-tagged, Recombinant, E.coli

Categories: [Proteins / Peptides]
PTTG1, also known as Securin, is primarily involved in the regulation of sister chromatid separation during cell division. It has two identified roles; the first one is to help the transport of separase(cysteine protease) to the nucleus and the second role is to inhibit the catalytic activity of separase. It is ubiquitinated by the Anaphase Promoting Complex (APC), and then degraded by the Proteasome, releasing separase.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP03604
Size 100 µg
Host E.coli
Accession
Molecular Weight 24.1 kDa (222aa)
AP_Mol_Weight
Tag
Sequences MGSSHHHHHHSSGLVPRGSHMATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDVELPPVCCDIDI
Purity > 95% by HPLC
Concentration 1 mg/ml (determined by Bradford assay)
Formulation Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 0.1 M NaCl, 20% glycerol, 1mM EDTA, 0.1mM PMSF.
Other Names Pituitary tumor-transforming protein 1, EAP1, HPTTG, PTTG, TUTR1
Bioactivity
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.
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