PNP, 1-289aa, Human, His tag, E.coli

PNP belongs to the PNP/MTAP phosphorylase family of proteins. This protein catalyzes the reversible phosphorolysis of ribonucleosides and 2’-deoxyribonucleosides with specificity for guanine, hypoxanthine and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in Tlymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficiency cases.