IRF-3 (S386 Phosphorylated) Anti-Human Rabbit IgG Affinity Purify

Regulatory transcription factor IRF-3 plays a critical role in the regulation of innate immune responses, especially production of IFN-α/β, against viral and bacterial infections. IRF-3 is ubiquitously expressed in its inactive form in the cytoplasm. Viral infection induces phosphorylation of the Ser 386 in IRF-3 by IRF-3 kinase (IKK-i/ε, TBK-1). This phosphorylation induces dimerization of IRF-3 and association with the coactivators CBP/p300, and the complex activates the target genes in the nucleus.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01265
Size 10 µg
Host Type Rabbit
Immunogen Synthetic peptide of the Phosphorylated C-terminal part of human IRF-3 (RVGGAS(pS)LEN)
Specificity
Isotype
Reacitivity Human
Clone
Uniprot
Concentration
Dilution
Formulation Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3
Application WB.
Other Names
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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