Fumarase Antibody (Clone AT3F6)

Fumarase (Fumarate hytdratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid (TCA), or Krebs cycle. This enzyme exists in both a cytosolic form and an N-terminal extended mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase deficiency can lead to progressive encephalopathy, cerebral atrophy and developmental delay and this enzyme also is thought to act as a tumor suppressor.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01260
Size 100 µL
Host Type Mouse
Immunogen Recombinant human Fumarase (44-510aa) purified from E. coli
Specificity
Isotype Mouse IgG2a, k
Reacitivity Human
Clone Anti-human Fumarase mAb, clone AT3F6, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Fumarase protein.
Uniprot
Concentration 1 mg/ml
Dilution
Formulation Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Application ELISA, WB, Flow cytometry, ICC/IF
Other Names Fumarate hydratase, FH, HLRCC, LRCC, MCL, MCuL1, Fumarate hydratase Fumarase, Fumarate hydratase mitochondrial, MCuL 1, Multiple hereditary cutaneous leiomyomata.
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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