ULBP1, 26-216aa , Human, His tag, E.coli

人ULBP1重组蛋白

ULBP1 is ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. In CMV infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Recombinant human ULBP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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基本信息

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货号 TP04424
规格 100 µg
宿主 E.coli
Accession
分子大小 25 kDa (216aa) confirmed by MALDI-TOF
AP_Mol_Weight
Tag N-6His
蛋白序列 MGSSHHHHHHSSGLVPRGSHMGSHMGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPG
纯度 > 95% by HPLC
浓度 0.5 mg/ml (determined by Bradford assay)
配方 Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT
别名 NKG2D ligand 1, UL16 binding protein 1, RAET1I, N2DL-1, N2DL1, NKG2D ligand 1
生物学活性
保存条件 4°C 短期保存 (1-2 周). 长期保存在 -20°C or -70°C. 避免反复冻融.
注意 仅用于科学研究, 不能用于疾病诊断.

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