UBQLN2 also known as ubiquilin-2. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation. Recombinant human UBQLN2, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.