Tubby-related protein 1, also known as TULP1, is a member of the TULP family of four proteins (TUB and TULP1, -2, and -3), characterized structurally by the highly conserved C-terminal half of the protein. In the retina, TULP1 is found exclusively in photoreceptor cells, localizing primarily in the inner segments and connecting cilium and to a lesser extent in the perinuclear cytoplasm and synaptic termini. Recombinant human TULP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.