TREM2 is a membrane protein that forms a receptorsignaling complex with the TYRO protein tyrosine kinase bindingprotein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production ofconstitutive inflammatory cytokines. Defects in this gene are acause of polycystic lipomembranous osteodysplasia with sclerosingleukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.