TNFRSF1A, also known as tumor necrosis factor receptor superfamily member 1A, is a member of CD family, tumor necrosis factor receptor superfamily. It is one of the most primary receptors for the tumor necrosis factor-alpha. It has been shown to be localized to both plasma membrane lipid rafts and the trans golgi complex with the help of the death domain. Recombinant human TNFRSF1A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.