TNFRSF13B, also known as tumor necrosis factor receptor superfamily member 13B, is a member of the tumor necrosis factor receptor superfamily. It is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). It cooperates with an adaptor protein which is important in determining the outcome of the response. It has crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Recombinant human TNFRSF13B, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.