Syndecan 4 belongs to syndecan proteoglycan family (type I integral membrane proteoglycans) that are involved in cell-extracellular matrix adhesion and growth factor binding. This protein functions cooperatively with integrins in the processes of cell spreading and focal adhesion assembly. It is also a transmembrane protein specifically enriched in Schwann cell perinodal processes. Recombinant Syndecan 4 protein was expressed in E.coli and purified by using conventional chromatography techniques.