STMN3, also known as stathmin3, is a 180 amino acid neuronal specific protein which belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. It is similar to the SCG10 protein and is involved in signal transduction and regulation of microtubule dynamics. Recombinant human STMN3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.