SCG5, also known as Neuroendocrine protein 7B2, is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 and is required for the production of an active PC2 enzyme. Recombinant human SCG5 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.