RPS7 belongs to the S3P family of ribosomal proteins and is located in the cytoplasm. RPS7 may play a role in ribosomal stress, linking ribosome biogenesis to cell death or cell cycle arrest. Also, RPS7 interacts with MDM2 and is believed to negatively regulate the MDM2-mediated degradation of p53. Recombinant human RPS7 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.