Rho-related GTP-binding protein RhoV, also known as RHOV, is a member of the Rho family and small GTPase superfamily. RHOV is a 236 amino acid protein that controls the actin cytoskeleton through activation of the JNK pathway. RHOV functions as a lipid anchor at the cytoplasmic side of the cell membrane and is expressed in placenta, pancreas and fetal brain. Recombinant human RHOV protein, fused to His-tag at Nterminus, was expressed in E.coli.