PSMA2, also known as proteasome subunit alpha type-2, is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. PSMA2, belonged to the peptidase T1A family, is a 20S core alpha subunit of proteasome. This protein serves as docking domains for the regulatory particles and exterior gates blocking unregulated access to the interior cavity.