PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. This protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. Recombinant human PROCR protein, fused to His-tag at N-terminus, was expressed in E.coli.