Prdx2 also known as peroxiredoxin-2 is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Prdx2 may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. If Prdx2 protection is inadequate against peroxidases, the resulting protein and DNA damage may result in neurological disease such as Alzheimer's or DNA damage leading to cancer. Recombinant rat Prdx2, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.