Phospholipid scramblase 1, also known as PLSCR1, may play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. This protein may contribute to cytokine-regulated cell proliferation and differentiation. Recombinant human PLSCR1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.